Guangrong Zheng Selected Research

Muscarinic Receptors (Muscarinic Acetylcholine Receptor)

2/2013

Structural modifications to tetrahydropyridine-3-carboxylate esters en route to the discovery of M5-preferring muscarinic receptor orthosteric antagonists.

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Guangrong Zheng Research Topics

Disease

30	Neoplasms (Cancer) 03/2024 - 01/2019
7	Thrombocytopenia (Thrombopenia) 03/2024 - 12/2019
4	Carcinogenesis 11/2020 - 01/2020
4	Tobacco Use Disorder (Nicotine Dependence) 12/2018 - 10/2007
3	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 03/2024 - 01/2023
3	Leukemia 10/2023 - 12/2019
3	Neoplasm Metastasis (Metastasis) 08/2023 - 01/2020
2	Body Weight (Weight, Body) 03/2024 - 03/2024
2	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2023 - 04/2020
2	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022 - 01/2022
2	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 01/2018
2	T-Cell Lymphoma (Lymphoma, T Cell) 08/2020 - 01/2020
2	Hematologic Neoplasms (Hematological Malignancy) 01/2020 - 01/2020
2	Cardiotoxicity 11/2019 - 01/2018
2	Substance-Related Disorders (Drug Abuse) 01/2019 - 02/2013
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2023
1	Lung Neoplasms (Lung Cancer) 01/2023
1	Ovarian Neoplasms (Ovarian Cancer) 01/2023
1	Glioma (Gliomas) 01/2022
1	Liver Neoplasms (Liver Cancer) 01/2022
1	Fibrolamellar hepatocellular carcinoma 01/2022
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022
1	Breast Neoplasms (Breast Cancer) 11/2020
1	Drug-Related Side Effects and Adverse Reactions 12/2019
1	Chronic Obstructive Pulmonary Disease (COPD) 01/2019
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2019
1	Carcinoma (Carcinomatosis) 01/2018
1	Teratocarcinoma 01/2018
1	Bacterial Infections (Bacterial Infection) 12/2017
1	Pain (Aches) 04/2011

Drug/Important Bio-Agent (IBA)

16	Proteins (Proteins, Gene)FDA Link 03/2024 - 01/2018
14	snake venom protein C activatorIBA 03/2024 - 12/2019
14	Proteolysis Targeting ChimeraIBA 03/2024 - 01/2020
8	DT2216IBA 03/2024 - 12/2019
5	UbiquitinIBA 03/2024 - 01/2022
5	navitoclaxIBA 03/2024 - 12/2019
5	Proteasome Endopeptidase Complex (Proteasome)IBA 03/2024 - 01/2022
5	Apoptosis Regulatory ProteinsIBA 10/2023 - 01/2020
3	LigandsIBA 01/2023 - 01/2019
3	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2023 - 01/2020
3	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 04/2011 - 10/2007
2	Annexin A5IBA 01/2022 - 01/2022
2	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2020
2	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2021
2	Ligases (Synthetase)IBA 01/2020 - 01/2020
2	Nicotine FDA Link 10/2015 - 10/2007
1	venetoclaxIBA 03/2024
1	Member 1 Group A Nuclear Receptor Subfamily 4IBA 08/2023
1	(5- (2,4- bis((3S)- 3- methylmorpholin- 4- yl)pyrido(2,3- d)pyrimidin- 7- yl)- 2- methoxyphenyl)methanolIBA 01/2023
1	Phosphotransferases (Kinase)IBA 01/2023
1	N- (5- (((5- (1,1- dimethylethyl)- 2- oxazolyl)methyl)thio)- 2- thiazolyl)- 4- piperidinecarboxamideIBA 01/2023
1	PlatinumIBA 01/2023
1	Tyrosine (L-Tyrosine)FDA Link 01/2023
1	Bcl-2-Like Protein 11IBA 01/2023
1	PLX 4720IBA 01/2023
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2023
1	Sincalide FDA Link 01/2022
1	Gemcitabine FDA Link 01/2022
1	Irinotecan (Camptosar)FDA LinkGeneric 01/2022
1	sotorasibIBA 01/2022
1	SenotherapeuticsIBA 10/2021
1	MethyltransferasesIBA 11/2020
1	Arginine (L-Arginine)FDA Link 11/2020
1	licochalcone AIBA 11/2020
1	Histone Deacetylases (Histone Deacetylase)IBA 08/2020
1	EnzymesIBA 04/2020
1	Antineoplastic Agents (Antineoplastics)IBA 12/2019
1	Ether (Diethyl Ether)IBA 11/2019
1	N- (1,2- dihydroxylpropyl)- 2,6- di- (4- methoxyphenethyl)piperidineIBA 11/2019
1	Cholinergic Agents (Cholinergics)IBA 01/2019
1	Methamphetamine (Desoxyn)FDA LinkGeneric 01/2018
1	Histone DemethylasesIBA 01/2018
1	Rifampin (Rifampicin)FDA LinkGeneric 12/2017
1	Clarithromycin (Biaxin)FDA LinkGeneric 12/2017
1	Conotoxins (Conotoxin)IBA 10/2015
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 02/2013
1	Analgesics (Analgesic Drugs)IBA 04/2011
1	Peptides (Polypeptides)IBA 04/2011
1	1- (3- picolinium)- 12- triethylammonium- dodecane dibromideIBA 10/2007

Therapy/Procedure

14	Therapeutics 03/2024 - 01/2019
5	Drug Therapy (Chemotherapy) 10/2023 - 12/2018
4	Immunotherapy 03/2024 - 01/2021
1	Precision Medicine 01/2023
1	Aftercare (After-Treatment) 01/2023
1	Radiotherapy 01/2019
1	Oral Administration 01/2018
1	Self Administration (Administration, Self) 10/2015